Second, in septic shock, obese patients may receive suboptimal exposure to AVP with conventional dosing strategies due to its rapid distribution into extracellular fluid, and volume of distribution being affected by weight-based fluid resuscitation and increased adipose tissue [36, 37]
Available from: Andrs E, Serraj K, Zhu J, Vermorken AJ
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However, once diagnosed it presents a difficult management problem in patients suffering from pernicious anemia, as there is no substitute
Studies have shown that at doses high enough to fully saturate intestinal B12 receptors, oral B12 is effective, despite a lack of intrinsic factor
The benefits of vitamin B12 include support for nerve function, red blood cell formation and energy production